Searchable abstracts of presentations at key conferences in endocrinology

ea0012p110 | Reproduction | SFE2006

The effect of different exogenous hormone regimens on body weight in female hooded-Lister rats

Sutcliffe JS , Marshall KM , Neill JC

The aim of this study was to evaluate the effects of estradiol ± different progestogens on body weight in ovariectomised mature female hooded-Lister rats.35 rats were ovariectomised under anaesthesia; following a recovery period animals were divided into 2 groups namely: (1) intermittent hormone dosing weeks 1–6 and 13–18, with no treatment weeks 7–12 and (2) delayed (no treatment in weeks 1–12) hormone treatment dosing weeks 13&...

ea0012p106 | Reproduction | SFE2006

Preliminary investigation on the effects of prostaglandin EP2 and EP4 agonists on isolated uterus from non-pregnant and pregnant mice

Griffiths AL , Marshall KM , Senior J , Woodward DF

The aim of this study was to compare the effects of prostaglandin EP2 – and EP4 -receptor agonists on uterine tissue taken from non-pregnant and pregnant mice.Uterine tissue was taken from non-pregnant animals during dioestrus and from pregnant animals on day 18 of gestation. Samples were set-up for superfusion (Krebs’ solution with 1 μM indometacin at 2 ml/min and 37 °C) as previously described by Senior et a...

ea0012p108 | Reproduction | SFE2006

The effect of smoking on prostaglandin (PG) biosynthesis and responsiveness in isolated human umbilical artery

Marshall KM , Duckworth NJ , Sumar N , Fleming K , Scott A

Studies have shown that maternal smoking causes intrauterine growth retardation and this may be as a result of endothelial dysfunction. It is possible that the prostaglandins may be involved in this mechanism. The aim of this study was to investigate the functional response of segments of human umbilical artery (HUA) to stable thromboxane (U46619) and prostacyclin (cicaprost) mimetics and measure the release of prostacyclin and thromboxane metabolites.Se...

ea0012p112 | Reproduction | SFE2006

Functional pharmacology of prostaglandin EP agonists in isolated human myometrium from term pregnant donors

Fischer DP , Farrar D , O’Donovan P , Senior J , Woodward DF , Marshall KM

Prostaglandin (PG) E2 acts through its receptors (EP1–4) to influence uterine contractility during gestation and parturition. The aim of the present study was to identify functional EP receptor targets in isolated myometrium from term pregnant, non-labouring donors by use of specific and novel EP agonists.Biopsies of human myometrium were obtained at elective caesarean section from consenting term pregnant women, not in labour ...